Searchable abstracts of presentations at key conferences in endocrinology

ea0099p111 | Pituitary and Neuroendocrinology | ECE2024

Deciphering microenvironment interactions during age-related pituitary tumour onset and through orthotopic mouse pre-clinical model

Flores-Martinez Alvaro , Chanal Marie , Daura Marine , Vasiljevic Alexandre , Bolbos Radu , Langlois Jean-Baptiste , Raverot Gerald , Bertolino Philippe

Rationale: Pituitary tumours (PiTs) are a common and heterogeneous group of benign, slow-growing intracranial neoplasms arising from the sellar region. While recent advances have improved our knowledge of their cellular composition and the contribution of their tumour microenvironment (TME), most of PiT subtypes lack effective therapeutic treatments. Moreover, the mechanisms that occur in the early stage of PiT initiation remain to be elucidated partly due to the limited numbe...